Luteolin O-methyltransferase
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Luteolin O-methyltransferase (EC 2.1.1.42) is an enzyme that catalyzes the chemical reaction
| Luteolin O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.42 | ||||||||
| CAS no. | 37205-55-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
This is a methylation reaction in which the flavone, luteolin, is converted to chrysoeriol. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which loses its methyl group and becomes S-adenosyl-L-homocysteine (SAH).[1]
Luteolin O-methyltransferase can also act on flavanols and converts quercetin to isorhamnetin:[2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase. Other names in common use include o-dihydric phenol methyltransferase, luteolin methyltransferase, luteolin 3'-O-methyltransferase, o-diphenol m-O-methyltransferase, o-dihydric phenol meta-O-methyltransferase, and S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase.[3] This enzyme participates in flavonoid biosynthesis and reacts with flavones in the 3' position, preferring those with a second hydroxy group adjacent in the 4' position.[4][5]
