MAL2 (gene)

AliasesMAL2, mal, T-cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2

External IDsOMIM: 609684; MGI: 2146021; HomoloGene: 14167; GeneCards: MAL2; OMA:MAL2 - orthologs

Chr.Chromosome 8 (human)^[1]

End119,245,673 bp^[1]

MAL2
Identifiers
Aliases	MAL2, mal, T-cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2
External IDs	OMIM: 609684; MGI: 2146021; HomoloGene: 14167; GeneCards: MAL2; OMA:MAL2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.12 Start 119,165,034 bp[1] End 119,245,673 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D1 Start 54,434,588 bp[2] End 54,466,243 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm oral cavity mucosa of pharynx nasal epithelium amniotic fluid palpebral conjunctiva human penis gums mucosa of colon mucosa of sigmoid colon Top expressed in subiculum right lung lobe epithelium of stomach Region I of hippocampus proper primary motor cortex mucous cell of stomach cingulate gyrus conjunctival fornix anterior amygdaloid area prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of myelin sheath Cellular component cytoplasm perinuclear region of cytoplasm plasma membrane extracellular exosome apical plasma membrane membrane endomembrane system membrane raft integral component of membrane integral component of synaptic vesicle membrane hippocampal mossy fiber to CA3 synapse glutamatergic synapse Biological process transcytosis membrane raft polarization protein localization myelination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114569 105853 Ensembl ENSG00000147676 ENSMUSG00000024479 UniProt Q969L2 Q8BI08 RefSeq (mRNA) NM_052886 NM_178920 RefSeq (protein) NP_443118 NP_443118.1 NP_849251 Location (UCSC) Chr 8: 119.17 – 119.25 Mb Chr 15: 54.43 – 54.47 Mb PubMed search [3] [4]
Wikidata
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Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.^[5][6]

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.^[6]