MALAT1
Non-coding RNA in the species Homo sapiens
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MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2) is an infrequently spliced long non-coding RNA, which is highly conserved amongst mammals and highly expressed in the nucleus.[3] It regulates the expression of metastasis-associated genes.[4] It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes.[5] MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta).[6]
| MALAT1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MALAT1, HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO2853, mascRNA, metastasis associated lung adenocarcinoma transcript 1 (non-protein coding), metastasis associated lung adenocarcinoma transcript 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607924; GeneCards: MALAT1; OMA:MALAT1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Conserved secondary structure in Metastasis associated lung adenocarcinoma transcript 1 | |
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 Predicted secondary structure and sequence conservation of MALAT1 | |
| Identifiers | |
| Symbol | MALAT1 |
| Rfam | RF01871 |
| Other data | |
| RNA type | Gene; |
| Domain | Eukaryota; |
| GO | GO:2000147 |
| SO | SO:0001263 |
| PDB structures | PDBe |
Expression in alcoholic brains
Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.[7]
