MAML1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.[5][6][7]
External IDsOMIM: 605424; MGI: 1890504; HomoloGene: 8845; GeneCards: MAML1; OMA:MAML1 - orthologs
Function
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.[7]
Details on the activity of the N-terminal domain of Mastermind-like protein 1 may be found under MamL-1.