MAPK12

MAPK12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CM8, 4QUM
Identifiers
Aliases	MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12
External IDs	OMIM: 602399; MGI: 1353438; HomoloGene: 55705; GeneCards: MAPK12; OMA:MAPK12 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,261,716 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,024,906 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; triceps brachii muscle; ; vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; right hemisphere of cerebellum; ; anterior pituitary; ; glutes; ; biceps brachii;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; temporal muscle; ; ankle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; gastrocnemius muscle; ; medial head of gastrocnemius muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein binding; ATP binding; magnesium ion binding; protein serine/threonine kinase activity; MAP kinase activity;
Cellular component	cytosol; mitochondrion; nucleoplasm; nucleus; cytoplasm;
Biological process	regulation of transcription, DNA-templated; phosphorylation; positive regulation of muscle cell differentiation; muscle organ development; negative regulation of cell cycle; transcription, DNA-templated; positive regulation of peptidase activity; protein phosphorylation; peptidyl-serine phosphorylation; DNA damage induced protein phosphorylation; cell cycle; myoblast differentiation; signal transduction; MAPK cascade; regulation of gene expression; intracellular signal transduction; cellular response to organic substance;
	Sources:Amigo / QuickGO
Orthologs
	6300
	29857
	ENSG00000188130
	ENSMUSG00000022610
	P53778
	O08911
	NM_002969; NM_001303252
	NM_013871
	NP_001290181; NP_002960
	NP_038899; NP_001389948; NP_001389949; NP_001389950; NP_001389951
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.^[5]