MCAT (gene)
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| MCAT | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MCAT, FASN2C, MCT, MT, NET62, fabD, malonyl-CoA-acyl carrier protein transacylase, MCT1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614479; MGI: 2388651; HomoloGene: 15511; GeneCards: MCAT; OMA:MCAT - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Malonyl CoA-acyl carrier protein transacylase, mitochondrial is an enzyme that in humans is encoded by the MCAT gene.[5][6]
The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein (mtACP). The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Two transcript variants encoding different isoforms have been found for this gene.[6]
Clinical significance
The enzyme encoded by the MCAT gene, along with other enzymes that regulate Malonyl-CoA concentration, have been shown to regulate levels such that malonyl-CoA concentration decreases in human muscle tissue when under exercise training. This enzyme specifically has increased activity under these conditions, as it is known to catabolize malonyl-CoA. [7]
