MDL-811

MDL-811
Clinical data
Drug class	Sirtuin-6 (SIRT6) activator
Identifiers
	IUPAC name N-(5-bromo-4-fluoro-2-methylphenyl)-4-[(3,5-dichlorophenyl)sulfonylamino]-2-[[(3R)-3-methylmorpholin-4-yl]methyl]benzenesulfonamide;
CAS Number	2275619-98-0;
PubChem CID	169450636;
ChemSpider	129309230;
ChEMBL	ChEMBL5275868;
Chemical and physical data
Formula	C25H25BrCl2FN3O5S2
Molar mass	681.41 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1COCCN1CC2=C(C=CC(=C2)NS(=O)(=O)C3=CC(=CC(=C3)Cl)Cl)S(=O)(=O)NC4=CC(=C(C=C4C)F)Br;
	InChI InChI=1S/C25H25BrCl2FN3O5S2/c1-15-7-23(29)22(26)12-24(15)31-39(35,36)25-4-3-20(8-17(25)13-32-5-6-37-14-16(32)2)30-38(33,34)21-10-18(27)9-19(28)11-21/h3-4,7-12,16,30-31H,5-6,13-14H2,1-2H3/t16-/m1/s1; Key:ULBHGKXUHYSORN-MRXNPFEDSA-N;

MDL-811 is a drug which acts as a sirtuin-6 (SIRT6) activator. It has antiinflammatory effects and shows neuroprotective effects in animal models of stroke and heart attack.^[1]^[2]^[3]^[4]

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