ME1 (gene)

PDBOrtholog search: PDBe RCSB

AliasesME1, HUMNDME, MES, malic enzyme 1

External IDsOMIM: 154250; MGI: 97043; HomoloGene: 134785; GeneCards: ME1; OMA:ME1 - orthologs

EC number1.1.1.40

ME1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AW5, 3WJA
Identifiers
Aliases	ME1, HUMNDME, MES, malic enzyme 1
External IDs	OMIM: 154250; MGI: 97043; HomoloGene: 134785; GeneCards: ME1; OMA:ME1 - orthologs
EC number	1.1.1.40
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.2 Start 83,210,402 bp[1] End 83,431,051 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E3.1|9 46.58 cM Start 86,463,424 bp[2] End 86,578,006 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii spinal ganglia trigeminal ganglion pars compacta skin of thigh pars reticulata right adrenal cortex vulva gums gingival epithelium Top expressed in adrenal gland lactiferous gland tunica adventitia of aorta mucous cell of stomach pyloric antrum right kidney epithelium of stomach subcutaneous adipose tissue brown adipose tissue zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function manganese ion binding ADP binding NAD binding metal ion binding NADP binding electron transfer activity malate dehydrogenase (decarboxylating) (NAD+) activity oxidoreductase activity oxaloacetate decarboxylase activity malic enzyme activity malate dehydrogenase (decarboxylating) (NADP+) activity Cellular component cytoplasm cytosol mitochondrion Biological process regulation of NADP metabolic process protein tetramerization NADP biosynthetic process response to hormone response to carbohydrate malate metabolic process regulation of lipid metabolic process carbohydrate metabolic process electron transport chain pyruvate metabolic process nucleotide biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4199 17436 Ensembl ENSG00000065833 ENSMUSG00000032418 UniProt P48163 P06801 RefSeq (mRNA) NM_002395 NM_001198933 NM_008615 RefSeq (protein) NP_002386 NP_001185862 NP_032641 Location (UCSC) Chr 6: 83.21 – 83.43 Mb Chr 9: 86.46 – 86.58 Mb PubMed search [3] [4]
Wikidata
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NADP-dependent malic enzyme is a protein that in humans is encoded by the ME1 gene.^[5][6]

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate to pyruvate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.^[6]