ME2 (gene)

PDBOrtholog search: PDBe RCSB

AliasesME2, ODS1, malic enzyme 2

External IDsOMIM: 154270; MGI: 2147351; HomoloGene: 37615; GeneCards: ME2; OMA:ME2 - orthologs

Chr.Chromosome 18 (human)^[1]

ME2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DO8, 1EFK, 1EFL, 1GZ3, 1GZ4, 1PJ2, 1PJ3, 1PJ4, 1PJL, 1QR6
Identifiers
Aliases	ME2, ODS1, malic enzyme 2
External IDs	OMIM: 154270; MGI: 2147351; HomoloGene: 37615; GeneCards: ME2; OMA:ME2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q21.2 Start 50,879,080 bp[1] End 50,954,257 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus jejunal mucosa cardiac muscle tissue of right atrium mucosa of colon mucosa of sigmoid colon monocyte duodenum right ventricle myocardium of left ventricle rectum n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function malate dehydrogenase (decarboxylating) (NAD+) activity electron transfer activity oxidoreductase activity NAD binding oxaloacetate decarboxylase activity catalytic activity metal ion binding malic enzyme activity malate dehydrogenase (decarboxylating) (NADP+) activity Cellular component mitochondrion mitochondrial matrix Biological process regulation of NADP metabolic process metabolism pyruvate metabolic process malate metabolic process electron transport chain tricarboxylic acid cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4200 107029 Ensembl ENSG00000082212 n/a UniProt P23368 Q99KE1 RefSeq (mRNA) NM_001168335 NM_002396 NM_145494 RefSeq (protein) NP_001161807 NP_002387 NP_663469 Location (UCSC) Chr 18: 50.88 – 50.95 Mb n/a PubMed search [2] [3]
Wikidata
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NAD-dependent malic enzyme, mitochondrial is a protein that in humans is encoded by the ME2 gene.^[4][5] This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.^[5]