MED17

Mediator of RNA polymerase II transcription subunit 17 is an enzyme that in humans is encoded by the MED17 gene.^[5][6][7]

AliasesMED17, CRSP6, CRSP77, DRIP80, TRAP80, mediator complex subunit 17, SRB4

External IDsOMIM: 603810; MGI: 2182585; HomoloGene: 3151; GeneCards: MED17; OMA:MED17 - orthologs

Chr.Chromosome 11 (human)^[1]

End93,814,963 bp^[1]

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MED17
Identifiers
Aliases	MED17, CRSP6, CRSP77, DRIP80, TRAP80, mediator complex subunit 17, SRB4
External IDs	OMIM: 603810; MGI: 2182585; HomoloGene: 3151; GeneCards: MED17; OMA:MED17 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q21 Start 93,784,227 bp[1] End 93,814,963 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A2 Start 15,171,647 bp[2] End 15,191,227 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve ventricular zone ganglionic eminence Achilles tendon left ovary right ovary canal of the cervix stromal cell of endometrium granulocyte body of uterus Top expressed in primary oocyte granulocyte zygote secondary oocyte epiblast ventricular zone morula endocardial cushion abdominal wall dermis More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coregulator activity thyroid hormone receptor binding protein binding nuclear receptor coactivator activity vitamin D receptor binding transcription coactivator activity signaling receptor activity ubiquitin protein ligase activity Cellular component membrane transcription regulator complex nucleoplasm mediator complex nucleus core mediator complex ubiquitin ligase complex Biological process androgen receptor signaling pathway regulation of transcription, DNA-templated intracellular steroid hormone receptor signaling pathway transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter protein ubiquitination stem cell population maintenance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9440 234959 Ensembl ENSG00000042429 ENSMUSG00000031935 UniProt Q9NVC6 Q8VCD5 RefSeq (mRNA) NM_004268 NM_144933 NM_001364533 RefSeq (protein) NP_004259 NP_659182 NP_001351462 Location (UCSC) Chr 11: 93.78 – 93.81 Mb Chr 9: 15.17 – 15.19 Mb PubMed search [3] [4]
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The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.^[7]