MED25

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesMED25, ACID1, ARC92, CMT2B2, P78, PTOV2, BVSYS, TCBAP0758, mediator complex subunit 25
Quick facts Available structures, PDB ...
MED25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMED25, ACID1, ARC92, CMT2B2, P78, PTOV2, BVSYS, TCBAP0758, mediator complex subunit 25
External IDsOMIM: 610197; MGI: 1922863; HomoloGene: 12614; GeneCards: MED25; OMA:MED25 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030973
NM_001378355

NM_029365
NM_001331206
NM_001331207
NM_001331208

RefSeq (protein)

NP_112235
NP_001365284

NP_001318135
NP_001318136
NP_001318137
NP_083641

Location (UCSC)Chr 19: 49.82 – 49.84 MbChr 7: 44.88 – 44.89 Mb
PubMed search[3][4]
Wikidata
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Intellectual developmental disorder

A homozygous variant in the MED25 gene, leading to an arginine to trypsin substitution, was identified in seven individuals with impaired intellectual development and characteristic facial features.[8] The genetic variant segregated with the disorder and was not found in control populations. This putative homozygous variant arose 218 years ago in this Brazilian family.[9]

Interactions

MED25 has been shown to interact with MED4.[10]

References

Further reading

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