MED31

Available protein structures:
PDB	IPR008831 PF05669 (ECOD; PDBsum)
AlphaFold	IPR008831; PF05669;

Med31
Med31
Identifiers
Symbol	Med31
Pfam	PF05669
InterPro	IPR008831
PDB
Available protein structures:
PDB	IPR008831 PF05669 (ECOD; PDBsum)
AlphaFold	IPR008831; PF05669;

MED31
Identifiers
Aliases	MED31, 3110004H13Rik, Soh1, CGI-125, mediator complex subunit 31
External IDs	MGI: 1914529; HomoloGene: 9368; GeneCards: MED31; OMA:MED31 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	6,651,634 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	72,106,418 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; bronchial epithelial cell; ; anterior pituitary; ; sperm; ; testicle; ; islet of Langerhans; ; prefrontal cortex; ; right adrenal gland; ; right adrenal cortex; ; nucleus accumbens;
	Top expressed in
	endocardial cushion; ; zygote; ; medial ganglionic eminence; ; facial motor nucleus; ; interventricular septum; ; secondary oocyte; ; atrioventricular valve; ; olfactory epithelium; ; morula; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription coactivator activity; transcription coregulator activity; protein binding; ubiquitin protein ligase activity;
Cellular component	core mediator complex; nucleus; nucleoplasm; ubiquitin ligase complex; mediator complex;
Biological process	regulation of transcription by RNA polymerase II; limb development; transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; negative regulation of fibroblast proliferation; protein ubiquitination; transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	51003
	67279
	ENSG00000108590
	ENSMUSG00000020801
	Q9Y3C7
	Q9CXU1
	NM_016060
	NM_026068
	NP_057144
	NP_080344
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 31 is a protein in humans encoded by the MED31 gene.^[5]^[6] It represents subunit Med31 of the Mediator complex. The family contains the Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant^[7] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes.^[8]