MINAR1

MINAR1
Identifiers
Aliases	MINAR1, membrane integral NOTCH2 associated receptor 1, KIAA1024, UBTOR
External IDs	OMIM: 618054; MGI: 2667167; GeneCards: MINAR1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	79,472,304 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	89,505,178 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; endothelial cell; ; testicle; ; cerebellar vermis; ; buccal mucosa cell;
	Top expressed in
	habenula; ; lumbar spinal ganglion; ; substantia nigra; ; medial vestibular nucleus; ; mammillary body; ; dorsal tegmental nucleus; ; pontine nuclei; ; ventral tegmental area; ; facial motor nucleus; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	membrane; integral component of membrane; plasma membrane;
Biological process	negative regulation of cell population proliferation; negative regulation of angiogenesis; angiogenesis; negative regulation of neuron projection development; negative regulation of cell growth; negative regulation of protein ubiquitination; negative regulation of TOR signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23251
	209743
	ENSG00000169330
	ENSMUSG00000039313
	Q9UPX6
	Q8K3V7
	NM_015206
	NM_153509
	NP_056021
	NP_705729
	Wikidata
View/Edit Human	View/Edit Mouse

Major intrinsically disordered Notch2-binding receptor 1 is a protein that in humans is encoded by the MINAR1 gene (previously KIAA1024).^[5] The MINAR1 protein regulates and inhibits mTOR signaling by stabilizing DEPTOR, an mTOR complex component.^[6] A notable homolog is MINAR2, which is sometimes called “major intrinsically disordered Notch2-binding receptor 1-like”.^[6]