ML-SA1

ML-SA1 is a chemical compound which acts as an "agonist" (i.e. channel opener) of the TRPML family of calcium channels. It has mainly been studied for its role in activating TRPML1 channels, although it also shows activity at the less studied TRPML2 and TRPML3 subtypes. TRPML1 is important for the function of lysosomes, and ML-SA1 has been used to study several disorders resulting from impaired lysosome function, including mucolipidosis type IV and Niemann-Pick's disease type C,^[1][2][3][4] as well as other conditions such as stroke and Alzheimer's disease.^[5][6]

CAS Number

• 332382-54-4

PubChem CID

• 2880983

ChemSpider

• 2155576

ChEMBL

• ChEMBL1527280

Quick facts Identifiers, CAS Number ...

ML-SA1

Identifiers
IUPAC name 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione
CAS Number	332382-54-4
PubChem CID	2880983
ChemSpider	2155576
ChEMBL	ChEMBL1527280
CompTox Dashboard (EPA)	DTXSID801336628
Chemical and physical data
Formula	C22H22N2O3
Molar mass	362.429 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1CC(N(C2=CC=CC=C12)C(=O)CN3C(=O)C4=CC=CC=C4C3=O)(C)C
InChI InChI=1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3 Key:KDDHBJICVBONAX-UHFFFAOYSA-N

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