MLA-74
Pharmaceutical compound
From Wikipedia, the free encyclopedia
MLA-74, also known as 1-methyllysergic acid ethylamide (1-methyl-LAE) or as 1-methyl-N-ethyllysergamide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][2][3] It is the 1-methyl derivative of lysergic acid ethylamide (LAE-32).[1][4][2][3] Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivatives, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed.[5][6]
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| Other names | MLA74; 1-Methyllysergic acid ethylamide; 1-Methyl-LAE; 1-Methyl-N-ethyllysergamide |
| Routes of administration | Oral |
| Drug class | Serotonin receptor modulator; Serotonergic psychedelic; Hallucinogen |
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| Formula | C19H23N3O |
| Molar mass | 309.413 g·mol−1 |
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Use and effects
An active dose of MLA-74 in humans is described as being approximately 2 mg orally and the drug is said to have about 4 to 5% of the potency of LSD.[1][2][7][8][9][10][11][12] It is also said to have a faster onset and shorter duration than LSD.[10][12] For comparison, LAE-32 has a listed dose range of 0.5 to 1.6 mg orally, approximately 5 to 10% of the potency of LSD, and is likewise described as faster onset and shorter duration.[1][2][7][8][9][10] MLA-74 is about 8-fold less potent than its analogue MLD-41 (1-methyl-LSD).[1] Both MLA-74 and LAE-32 are described as producing LSD-like psychic effects in humans.[10][12] However, they are both described as producing only slight or weak hallucinogenic effects.[13]
Interactions
Pharmacology
Pharamcodynamics
MLA-74 shows about 8.35 times the antiserotonergic activity of LSD in the isolated rat uterus in vitro and about 70-fold the activity of LAE-32 in this assay.[1][14][15][12] Unlike LAE-32, MLA-74 is practically devoid of pyretogenic effects in rabbits and is listed as having 0% of the activity of LSD in this regard.[1][14]
History
MLA-74 was first described in the scientific literature by the late 1950s.[15][16][11][12]
See also
- Substituted lysergamide
- MLD-41 (1-methyl-LSD)
- MPD-75 (1-methyl-LPD)
- ALA-10 (1-acetyl-LAE; 1A-LAE)