MLST8

MLST8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JSN, 4JSP, 4JSV, 4JSX, 4JT5, 4JT6, 5FLC
Identifiers
Aliases	MLST8, GBL, GbetaL, LST8, POP3, WAT1, MTOR associated protein, LST8 homolog
External IDs	OMIM: 612190; MGI: 1929514; HomoloGene: 6833; GeneCards: MLST8; OMA:MLST8 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,209,453 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,698,052 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; anterior cingulate cortex; ; muscle of thigh; ; apex of heart; ; Brodmann area 9; ; amygdala; ; nucleus accumbens; ; left testis;
	Top expressed in
	granulocyte; ; neural layer of retina; ; Ileal epithelium; ; genital tubercle; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; spermatocyte; ; primary visual cortex; ; muscle of thigh; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein serine/threonine kinase activator activity;
Cellular component	cytoplasm; nucleoplasm; cytosol; TORC1 complex; TORC2 complex;
Biological process	positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization; regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; regulation of cellular response to heat; TORC1 signaling; positive regulation of protein serine/threonine kinase activity; regulation of macroautophagy; activation of protein kinase B activity; TOR signaling; positive regulation of TOR signaling;
	Sources:Amigo / QuickGO
Orthologs
	64223
	56716
	ENSG00000167965
	ENSMUSG00000024142
	Q9BVC4
	Q9DCJ1
NM_001199173; NM_001199174; NM_001199175; NM_022372; NM_001352057;
	NM_001352059; NM_001352060
	NM_001252463; NM_001252464; NM_001252465; NM_019988
NP_001186102; NP_001186103; NP_001186104; NP_071767; NP_001338986;
	NP_001338988; NP_001338989
	NP_001239392; NP_001239393; NP_001239394; NP_064372
	Wikidata
View/Edit Human	View/Edit Mouse

Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 (mLST8) or TORC subunit LST8 or G protein beta subunit-like (GβL or Gable), is a protein that in humans is encoded by the MLST8 (MTOR associated protein, LST8 homolog) gene.^[5] It is a subunit of both mTORC1 and mTORC2, complexes that regulate cell growth and survival in response to nutrient, energy, redox, and hormonal signals.^[6] It is upregulated in several human colon and prostate cancer cell lines and tissues. Knockdown of mLST8 prevented mTORC formation and inhibited tumor growth and invasiveness.^[7]