MLX (gene)

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Max-like protein X is a protein that in humans is encoded by the MLX gene.[5][6]

AliasesMLX, MAD7, MXD7, TCFL4, bHLHd13, MAX dimerization protein, TF4, MAX dimerization protein MLX
End42,573,239 bp[1]
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MLX
Identifiers
AliasesMLX, MAD7, MXD7, TCFL4, bHLHd13, MAX dimerization protein, TF4, MAX dimerization protein MLX
External IDsOMIM: 602976; MGI: 108398; HomoloGene: 7969; GeneCards: MLX; OMA:MLX - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198205
NM_170607
NM_198204
NM_013383
NM_170608

NM_001159384
NM_001159385
NM_011550

RefSeq (protein)

NP_733752
NP_937847
NP_937848

NP_001152856
NP_001152857
NP_035680

Location (UCSC)Chr 17: 42.57 – 42.57 MbChr 11: 100.98 – 100.98 Mb
PubMed search[3][4]
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Function

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[6]

Interactions

MLX (gene) has been shown to interact with MNT,[7][8] MXD1[7][8] and MLXIPL.[7]

MLX must dimerize with MondoA[9] or with MLXIPL (carbohydrate-responsive element-binding protein) to regulate target genes.[10]

References

Further reading

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