MPHOSPH10

U3 small nucleolar ribonucleoprotein protein MPP10 is a protein that in humans is encoded by the MPHOSPH10 gene.^[5][6][7]

AliasesMPHOSPH10, CT90, MPP10, MPP10P, PPP1R106, M-phase phosphoprotein 10

External IDsOMIM: 605503; MGI: 1915223; HomoloGene: 134741; GeneCards: MPHOSPH10; OMA:MPHOSPH10 - orthologs

Chr.Chromosome 2 (human)^[1]

End71,150,101 bp^[1]

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MPHOSPH10
Identifiers
Aliases	MPHOSPH10, CT90, MPP10, MPP10P, PPP1R106, M-phase phosphoprotein 10
External IDs	OMIM: 605503; MGI: 1915223; HomoloGene: 134741; GeneCards: MPHOSPH10; OMA:MPHOSPH10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 71,130,310 bp[1] End 71,150,101 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 C Start 64,026,275 bp[2] End 64,042,016 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii endometrium mucosa of esophagus oral cavity pars compacta glutes pericardium hair follicle mucosa of pharynx Top expressed in genital tubercle zygote tail of embryo secondary oocyte primary oocyte epiblast primitive streak fetal liver hematopoietic progenitor cell morula morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component sno(s)RNA-containing ribonucleoprotein complex small-subunit processome Mpp10 complex nucleolus nucleus chromosome nucleoplasm Biological process RNA splicing, via transesterification reactions negative regulation of phosphatase activity RNA processing ribosome biogenesis RNA splicing rRNA processing maturation of SSU-rRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10199 67973 Ensembl ENSG00000124383 ENSMUSG00000030521 UniProt O00566 Q810V0 RefSeq (mRNA) NM_005791 NM_026483 RefSeq (protein) NP_005782 NP_080759 Location (UCSC) Chr 2: 71.13 – 71.15 Mb Chr 7: 64.03 – 64.04 Mb PubMed search [3] [4]
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This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein is thought to be part of the U3 small nucleolar ribonucleoprotein complex, which is involved in rRNA processing.^[7]