MPP2

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesMPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2

External IDsOMIM: 600723; MGI: 1858257; HomoloGene: 3920; GeneCards: MPP2; OMA:MPP2 - orthologs

Chr.Chromosome 17 (human)^[1]

Quick facts Available structures, PDB ...

MPP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E7K
Identifiers
Aliases	MPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2
External IDs	OMIM: 600723; MGI: 1858257; HomoloGene: 3920; GeneCards: MPP2; OMA:MPP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,875,357 bp[1] End 43,909,711 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 65.48 cM Start 101,947,841 bp[2] End 101,979,341 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment prefrontal cortex right hemisphere of cerebellum right frontal lobe hypothalamus Brodmann area 9 cingulate gyrus anterior cingulate cortex amygdala substantia nigra Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex subiculum superior frontal gyrus piriform cortex dorsomedial hypothalamic nucleus neural layer of retina superior colliculus primary motor cortex anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanylate kinase activity protein binding Cellular component integral component of plasma membrane postsynaptic density dendrite membrane dendritic spine dendritic shaft cytoplasm cytoskeleton plasma membrane membrane dendrite dendritic spine membrane cell projection Biological process signal transduction GMP metabolic process GDP metabolic process protein homooligomerization excitatory postsynaptic potential long-term potentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4355 50997 Ensembl ENSG00000108852 ENSMUSG00000017314 UniProt Q14168 Q9WV34 RefSeq (mRNA) NM_001278370 NM_001278371 NM_001278372 NM_001278373 NM_001278374 NM_001278375 NM_001278376 NM_001278381 NM_005374 NM_016695 NM_001356324 RefSeq (protein) NP_001265299 NP_001265300 NP_001265301 NP_001265302 NP_001265303 NP_001265304 NP_001265305 NP_001265310 NP_005365 NP_057904 NP_001343253 Location (UCSC) Chr 17: 43.88 – 43.91 Mb Chr 11: 101.95 – 101.98 Mb PubMed search [3] [4]
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Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.^[6]