MRK-016

MRK-016
Names
	Preferred IUPAC name 3-tert-Butyl-7-(5-methyl-1,2-oxazol-3-yl)-2-[(1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine
Identifiers
CAS Number	342652-67-9 ;
3D model (JSmol)	Interactive image;
ChemSpider	5293780;
PubChem CID	6918583;
UNII	TXZ4DVJ9MF ;
CompTox Dashboard (EPA)	DTXSID60426080;
	InChI InChI=1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3 Key: QYSYOGCIDRANAR-UHFFFAOYSA-N;
	SMILES CN1N=CN=C1COC1=NN2C(C=NN=C2C2=NOC(C)=C2)=C1C(C)(C)C;
Properties
Chemical formula	C17H20N8O2
Molar mass	368.401 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

MRK-016 is a selective α₅ subunit-containing GABA_A negative allosteric modulator,^[1] that has nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression.^[2]

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Names

Preferred IUPAC name 3-tert-Butyl-7-(5-methyl-1,2-oxazol-3-yl)-2-[(1H-1,2,4-triazol-5-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazine
Identifiers
CAS Number	342652-67-9^Y
3D model (JSmol)	Interactive image
ChemSpider	5293780
PubChem CID	6918583
UNII	TXZ4DVJ9MF^Y
CompTox Dashboard (EPA)	DTXSID60426080
InChI InChI=1S/C17H20N8O2/c1-10-6-11(23-27-10)15-21-19-7-12-14(17(2,3)4)16(22-25(12)15)26-8-13-18-9-20-24(13)5/h6-7,9H,8H2,1-5H3 Key: QYSYOGCIDRANAR-UHFFFAOYSA-N
SMILES CN1N=CN=C1COC1=NN2C(C=NN=C2C2=NOC(C)=C2)=C1C(C)(C)C
Properties
Chemical formula	C₁₇H₂₀N₈O₂
Molar mass	368.401 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references