MRN complex-interacting protein

MRNIP
Identifiers
Aliases	MRNIP, C5orf45, MRN complex interacting protein
External IDs	OMIM: 617154; MGI: 1915317; GeneCards: MRNIP
Gene location (Human)
Chr.	Chromosome 5 (human)
End	179,862,173 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	50,090,942 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; right uterine tube; ; pituitary gland; ; anterior pituitary; ; left ovary; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; canal of the cervix; ; right ovary;
	Top expressed in
	blastocyst; ; zygote; ; secondary oocyte; ; primary oocyte; ; genital tubercle; ; right kidney; ; proximal tubule; ; spermatocyte; ; yolk sac; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	chromatin binding; protein binding;
Cellular component	nucleus; nucleoplasm; Mre11 complex;
Biological process	DNA repair; cellular response to DNA damage stimulus; mitotic G2 DNA damage checkpoint signaling; response to ionizing radiation; positive regulation of protein kinase activity; protein localization to chromatin; positive regulation of double-strand break repair via homologous recombination; regulation of double-strand break repair via nonhomologous end joining;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51149
	68067
	ENSG00000161010; ENSG00000283918
	ENSMUSG00000020381
	Q6NTE8
	Q9D1F5
	NM_016175; NM_001017987; NM_001018061; NM_001018062
	NM_026543
	NP_001017987; NP_057259
	NP_080819
	Wikidata
View/Edit Human	View/Edit Mouse

MRN complex-interacting protein is a protein that in humans is encoded by the MRNIP gene (previously C5orf45).^[5] The MRNIP protein is involved with DNA repair through its interaction with the MRN complex.^[5]