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MT-7716

Nociceptin receptor agonist From Wikipedia, the free encyclopedia

MT-7716 is an experimental opioid drug that could potentially be used in the treatment of alcohol addiction.

Quick facts Names, Identifiers ...
MT-7716
Names
IUPAC name
2-[3-[1-[(1R)-1,2-Dihydroacenaphthylen-1-yl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1
    Key: PJANMOWVUZBDQF-XMMPIXPASA-N
  • CNC(=O)CN1C2=CC=CC=C2N(C1=O)C3CCN(CC3)[C@@H]4CC5=CC=CC6=C5C4=CC=C6
Properties
C27H28N4O2
Molar mass 440.547 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mechanism of action

Unlike most opioids, MT-7716 does not appear to act through delta, kappa and mu opioid receptors, but instead is an agonist of the nociceptin receptor.[1]

Alcohol addiction

A study has shown that MT-7716 was able to decrease alcohol self-administration and reduce alcohol withdrawal symptoms in rats.[2]

Another study was also able to show similar results, in addition to demonstrating MT-7716's ability to suppress stress-induced alcohol seeking.[3]

References

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