Madame Morrible

In the novel, Madame Morrible is described as a "fish faced Gillikinese woman", and uses Shiz to recruit young girls as soldiers and spies for the Wizard, though she does not directly influence him. Madame Morrible believes that Animals (i.e. sentient animals) should be "seen and not heard", which she states at a poetry reading, known as a 'Quell'. She often has a Tik-Tok machine man called Grommetik to do her bidding, and later commands this creature to kill the Goat scientist Doctor Dillamond, which Ama Clutch—Galinda's chaperone—witnesses. Following the murder, Ama Clutch loses her grip on reality and begins to talk to inanimate objects as though they are people, a condition which gradually deteriorates until it results in her death. Galinda had previously lied to Madame Morrible by telling her that Ama Clutch was prone to fits of delirium whose symptoms included such hallucinations; since she had told no one else this lie, it is strongly implied that the condition was the result of a spell placed upon Ama Clutch by Morrible to prevent her from revealing the truth about Doctor Dillamond's murder.

At the funeral of Ama Clutch, Madame Morrible suggests to Nessarose, Elphaba and Glinda that the three become the "Adepts" of Quadling Country, Munchkinland and Gillikin respectively. This would grant them political dominion over these areas, but, as Morrible admits, is in fact a way of maintaining the Wizard's authority in far-flung regions of Oz. They all reject the idea, however each girl does ultimately find herself the ruler of a region in Oz: Nessarose becomes the Eminence of the East (a.k.a. "Wicked Witch of the East"), Elphaba rules the Vinkus as the "Wicked Witch of the West", and Glinda rules Gillikin as the Good Witch of the North. Later in the novel, Elphaba speculates that Madame Morrible was a witch, and may somehow have influenced events to bring the three to power despite their original refusal. The theory of Morrible's having magical powers is indeed probably correct, as she successfully immobilized the three girls with a binding spell while speaking to them of their future as Adepts, as well as somehow making it impossible for them to discuss the matter afterward. She also claimed that her "special talent is to encourage talent", which may support the latter theory as well.

Throughout the novel, Elphaba stands by her belief that Madame Morrible was behind the death of Doctor Dillamond. While involved in a resistance movement against the Wizard, Elphaba is assigned to assassinate Madame Morrible, who is staying in the Emerald City. However, Morrible surrounds herself with children, and Elphaba is forced to abandon her plan to avoid harming innocent bystanders. Toward the end of the story, Elphaba goes to Shiz and tries to kill Madame Morrible by bashing her head in with a marble trophy, but is five minutes too late, and ends up merely assaulting the woman's corpse (though she later takes credit for having killed her).