Malaprade reaction
From Wikipedia, the free encyclopedia
In organic chemistry, the Malaprade reaction or Malaprade oxidation is a reaction that converts vicinal diols by periodic acid or a periodate salt to give a pair of carbonyl derivatives.[1][2] The reaction was first reported by Léon Malaprade in 1928.[3][4] Amino alcohols are also cleaved.[5]
In terms of mechanism, the reaction is assumed to proceed by formation of cyclic diester of iodine(VII).[6]
