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Maleylpyruvate isomerase

Class of enzymes From Wikipedia, the free encyclopedia

Maleylpyruvate isomerase (EC 5.2.1.4) is an enzyme that catalyzes the chemical reaction

2D representation of the chemical structure of 3-Maleylpyruvic acid .
3-Maleylpyruvic acid
 
 
 
Reversible left-right reaction arrow
 
 
 
2D representation of the chemical structure of 3-Fumarylpyruvic acid.
3-Fumarylpyruvic acid
EC no.5.2.1.4
CAS no.9023-77-2
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Maleylpyruvate isomerase
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EC no.5.2.1.4
CAS no.9023-77-2
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The enzyme has one substrate, 3-maleylpyruvic acid, which it converts to its geometric isomer, 3-fumarylpyruvic acid.[1][2]

This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. The systematic name of this enzyme class is 3-maleylpyruvate cis-trans-isomerase. This enzyme participates in tyrosine metabolism.[3]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 2NSF​ and PDB: 2NSG​.

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