Mandelate 4-monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Mandelate 4-monooxygenase (EC 1.14.16.6) is an enzyme that catalyzes the chemical reaction
-Tetrahydrobiopterin_structure.svg)
-4-hydroxymandelic_acid.svg)
-L-erythro-6,7-dihydrobiopterin.svg)
-mandelic_acid.svg)
| Mandelate 4-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.16.6 | ||||||||
| CAS no. | 39459-82-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are (S)-mandelic acid, tetrahydrobiopterin, and oxygen. Its products are (S)-4-hydroxymandelic acid, dihydrobiopterin, and water.[1][2]
This enzyme characterised from Pseudomonas convexa is an oxidoreductase that uses molecular oxygen as oxidant. A reduced pteridine is required. The systematic name of this enzyme class is (S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating). Other names in common use include L-mandelate 4-hydroxylase, and mandelic acid 4-hydroxylase. It employs one cofactor, iron.[1]
