Mannitol dehydrogenase (cytochrome)
Enzyme class
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In enzymology, mannitol dehydrogenase (cytochrome) (EC 1.1.2.2) is an enzyme that catalyzes the chemical reaction
| mannitol dehydrogenase (cytochrome) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.2.2 | ||||||||
| CAS no. | 37250-78-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The substrate of this enzyme is D-mannitol, which is acted on by two equivalents of the cofactor, ferricytochrome c, which oxidises one of the hydroxy groups to a keto group, giving D-fructose, while the cofactor's iron is reduced.[1][2][3]
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is D-mannitol:ferricytochrome-c 2-oxidoreductase. This enzyme is also called polyol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism
