Mannosyl-3-phosphoglycerate synthase
Class of enzymes
From Wikipedia, the free encyclopedia
Mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) is an enzyme that catalyzes the chemical reaction
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| Mannosyl-3-phosphoglycerate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.217 | ||||||||
| CAS no. | 393512-63-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The two substrates of this enzyme characterised from Pyrococcus horikoshii are 3-phospho-D-glyceric acid and GDP-mannose. Its products are 2-(α-D-mannosyl)-3-phosphoglyceric acid (mannosyl-3-phosphoglycerate) and guanosine diphosphate (GDP). In this thermophilic bacteria, the product has its phosphate group removed by hydrolysis by the enzyme mannosyl-3-phosphoglycerate phosphatase. This gives a compound, mannosylglycerate, which acts to protect against osmotic shock.[1]
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase. This enzyme is also called MPG synthase.[2]
