Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
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Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase, also known as Golgi α-mannosidase II, is an enzyme with systematic name (1â3)-(1â6)-mannosyl-oligosaccharide α-D-mannohydrolase.[1][2][3][4] It catalyses the hydrolysis of the terminal (1â3)- and (1â6)-linked α-D-mannose residues in the mannosyl-oligosaccharide Man5(GlcNAc)3.
Alt. namesmannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase
| Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.1.114 | ||||||||
| CAS no. | 82047-77-6 | ||||||||
| Alt. names | mannosidase II, exo-1,3-1,6-α-mannosidase, α-D-mannosidase II, α-mannosidase II, α-3,6-mannosidase, GlcNAc transferase I-dependent α1,3[α1,6]mannosidase, Golgi α-mannosidase II, ManII, 1,3(1,6)-α-D-mannosidase, 1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is involved in the synthesis of glycoproteins. It is a key enzyme of N-linked glycan processing and is inhibited by small molecule swainsonine.[5]
