Facchini's researches the chemical and physical processes of aerosols in the atmosphere, both natural (clouds) and man-made, and how these processes affect phenomena including regional air quality, ultraviolet radiation levels, and climate. These impact, as her group's website puts it, "the fundamental necessities of human existence", such as human health, food production, and water resources.[3][1]
Based at the University of Bologna since the 1980s, Facchini took from Riccado Valentini as the director of research at the Institute of Atmospheric Sciences and Climate (ISAC) of the Italian National Research Council in January 2023.[2][1] She has published over 150 papers in peer-reviewed publications as of 2015.[2] She is on multiple panels and boards, including the Scientific Advisory Board of the Max Planck Institute for Chemistry in Mainz, Germany since 2011, and the Council of European Geochemistry Society.[4] She was a lead author of Chapter 1 of the Working Group I Fifth Assessment Report of the Intergovernmental Panel on Climate Change.[2] Facchini is president of the Italian Society of Climate Sciences since 2023.[5]
Facchini was a co-author on the paper that won the 2014 Haagen-Smit Prize, "in recognition of its excellent contribution to the studies of aerosol observations in different areas in Europe".[6] She was also appointed a Commendatore of the Italian Republic.[7][1]