His first entry into his career was when he was recommended for an internship with Aaron Spelling and Nolan Miller, a television producer and fashion designer respectively.[2] Through his work with Nolan, Zunino was able to work with multiple people, such as Nancy Reagan,[3] Elizabeth Taylor,[4] Joan Collins, Mariah Carey, Jennifer Lopez and Britney Spears.[5][6] These experiences, combined with his exposure to the couture business among others, helped inform his focus on an “old Hollywood” style.[6] Zunino later launched a fashion line in 1998, which was designed to have more “modern” sensibilities.[6] He later debuted the “Mark Zunino” line and accepted a partnership with Miller.[2] The partnership lasted from 1998-2007 when it was dissolved due to Miller being diagnosed with lung cancer. Zunino relaunched it under his own name.[2] He toured internationally from 2007–2011 in partnership with General Motors.[7] He launched multiple fashion lines in 2011, including Mark Zunino Bridal and MZ2, which was relatively budget-priced.[2] He opened a salon in Beverly Hills, CA in 2015.[2]