Bettoni was born in Borgosesia, she started playing rugby in 2008 in Piedmont, aged 17 as an agricultural student, with a small club called Valsesia before establishing herself for the Red & Blu Rugby club in the Serie A competition.[1]
On 12 February 2012, She made her test debut together with Michela Sillari in Recco, in a very tough match against England during the Six Nations Championship.[1] In 2012 she made her first appearance for Grenoble before spending a semester in New Zealand.
Having returned to Italy, she became a regular in the national team and was decisive in their 2014 Six Nations win over Wales, she scored a try in the 61st minute which saw the Azzurre make a comeback from 0–8 down with 19 minutes to go.
In 2014, after a further season in Rome, she moved again to France to play for Stade Rennais, alternating her sporting activity with her work as a babysitter; she was part of the team called up by coach Andrea Di Giandomenico for the 2017 Women's Rugby World Cup in Ireland, where Italy finished ninth.
On 9 September 2022, during a warm-up win against France in preparation for the World Cup, Melissa Bettoni took on the role of captain for the first time due to an injury sustained by captain Manuela Furlan.
At the end of the World Cup she retired from rugby which she had announced at the end of her last season in France,[2] to open an Italian restaurant with her French husband; she boasts a total of 76 international matches with 14 tries scored for Italy.[2]
In 2023, Bettoni rejoined Le Azzurre as a forwards coach for the Italy women’s U-20 team.[2]
