Menthofuran

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Menthofuran
Names
IUPAC name
3,6-Dimethyl-4,5,6,7-tetrahydro-1-benzofuran
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.007.087 Edit this at Wikidata
UNII
  • InChI=1S/C10H14O/c1-7-3-4-9-8(2)6-11-10(9)5-7/h6-7H,3-5H2,1-2H3
    Key: YGWKXXYGDYYFJU-UHFFFAOYSA-N
  • InChI=1/C10H14O/c1-7-3-4-9-8(2)6-11-10(9)5-7/h6-7H,3-5H2,1-2H3
    Key: YGWKXXYGDYYFJU-UHFFFAOYAW
  • o1c2c(c(c1)C)CCC(C2)C
Properties
C10H14O
Molar mass 150.221 g·mol−1
Boiling point 208
Hazards
Flash point 86
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Menthofuran is an organic compound found in a variety of essential oils including that of pennyroyal (Mentha pulegium). It is highly toxic and believed to be the primary toxin in pennyroyal responsible for its potentially fatal effects.[1] After ingestion of menthofuran, it is metabolically activated to chemically reactive intermediates that are hepatotoxic.[2]

(+)-Menthofuran is produced in plants such as peppermint from pulegone by the enzyme menthofuran synthase.[3]

2D representation of the chemical structure of pulegone .
pulegone
 
O2
2 H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q27107323.
(+)-menthofuran

Chemistry

Pharmacology

References

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