Mepiprazole

Chemical compound From Wikipedia, the free encyclopedia

Mepiprazole (INN, BAN; brand name Psigodal) is an anxiolytic drug of the phenylpiperazine group with additional antidepressant properties[1] that is marketed in Spain.[2][3][4][5][6] It acts as a 5-HT2A and α1-adrenergic receptor antagonist[7][8][9] and inhibits the reuptake and induces the release of serotonin, dopamine, and norepinephrine to varying extents,[1][9] and has been described as a serotonin antagonist and reuptake inhibitor (SARI).[10]

Trade namesPsigodal
Other namesPAP; EMD-16923; H-4007
Routes of
administrationOral
Drug classSerotonin antagonist and reuptake inhibitor (SARI); Serotonin 5-HT2A receptor antagonist; α1-Adrenergic receptor antagonist; Serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)
Quick facts Clinical data, Trade names ...
Mepiprazole
Clinical data
Trade namesPsigodal
Other namesPAP; EMD-16923; H-4007
Routes of
administration		Oral
Drug classSerotonin antagonist and reuptake inhibitor (SARI); Serotonin 5-HT2A receptor antagonist; α1-Adrenergic receptor antagonist; Serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI)
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-(3-Chlorophenyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethyl]piperazine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H21ClN4
Molar mass304.82 g·mol−1
3D model (JSmol)
  • Cc3cc(CCN2CCN(c1cccc(Cl)c1)CC2)n[nH]3
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Uses

Controlled clinical trials of mepiprazole in patients with irritable bowel syndrome (IBS) were also carried out and suggested some benefits of the drug in relieving symptoms of IBS in some patients.[11] Similarly to other phenylpiperazines like trazodone, nefazodone, and etoperidone, mepiprazole produces mCPP as an active metabolite.[12]

See also

References

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