Methamnetamine
Chemical compound
From Wikipedia, the free encyclopedia
Methamnetamine (also known as methylnaphetamine, MNA, MNT, MNAP, PAL-1046, and MY-10) is a triple monoamine releasing agent of the amphetamine and naphthylaminopropane families. It is the N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine.[2][3][4] It has been sold online as a designer drug between 2015 and 2016.[5][6][7]
Other namesMethylnaphetamine; MNA; MNT; MNAP; PAL-1046; MY-10;[1] N-Methylnaphthylaminopropane; N-Methylnaphthylisopropylamine
Legal status
- DE: NpSG (Industrial and scientific use only)
- UK: Under Psychoactive Substances Act
- Illegal in Japan
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| Other names | Methylnaphetamine; MNA; MNT; MNAP; PAL-1046; MY-10;[1] N-Methylnaphthylaminopropane; N-Methylnaphthylisopropylamine |
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| Formula | C14H17N |
| Molar mass | 199.297 g·mol−1 |
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Pharmacology
Pharmacodynamics
Methamnetamine acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively.[2] It is also a lower-potency partial agonist of the serotonin 5-HT2A receptor.[8]
| Compound | NE | DA | 5-HT | Ref |
|---|---|---|---|---|
| d-Amphetamine | 6.6–10.2 | 5.8–24.8 | 698–1,765 | [9][10][11][12][13] |
| Naphthylaminopropane (NAP; PAL-287) | 11.1 | 12.6 | 3.4 | [14][11] |
| d-Methamphetamine | 12.3–14.3 | 8.5–40.4 | 736–1,292 | [9][15][11][13] |
| Methylnaphthylaminopropane (MNAP; PAL-1046) | 34 | 10 | 13 | [16][17] |
| l-Methcathinone | 13.1 | 14.8 | 1,772 | [18][12] |
| 2-Naphthylmethcathinone (BMAPN; βk-MNAP) | 94% at 10 μM | 34 | 27 | [19][20] |
| d-Ethylamphetamine | 28.8 | 44.1 | 333.0 | [21][22] |
| Ethylnaphthylaminopropane (ENAP; PAL-1045) | 137 | 46 a | 12 a | [16] |
| Phenmetrazine | 29–50.4 | 70–131 | 7,765–>10,000 | [23][11][24][25] |
| Naphthylmetrazine (PAL-704) | 203 | 111 | RI (105) | [25] |
| Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Footnotes: a ENAP is a partial releaser of serotonin (Emax = 66%) and dopamine (Emax = 78%). Refs:[26][27] | ||||
Society and culture
Legal status
Methamnetamine is illegal in Japan.[28]