Methyldesorphine

Methyldesorphine is an opioid analgesic. First synthesized in Germany in 1940 and patented in the US in 1952,^[2] it has a high potential for abuse as with any potent opioid agonist, and is sometimes found along with desomorphine as a component of the home-made opioid mixture known as "Krokodil" used in Russia and the neighboring former Soviet republics.^[3] It is approximately 15 times more potent than morphine as an analgesic,^[4][5] but if the 6-7 bond is saturated, the β isomer is some 50 times more potent than morphine.

Other names3-Hydroxy-6,N-dimethyl-4,5-epoxymorphin-6-en

ATC code

• none

Legal status

• AU: S9 (Prohibited substance)
• BR: Class A1 (Narcotic drugs)^[1]
• CA: Schedule I
• DE: Anlage I (Authorized scientific use only)
• US: Schedule I

CAS Number

• 16008-36-9 ^Y

Quick facts Clinical data, Other names ...

Methyldesorphine

Clinical data
Other names	3-Hydroxy-6,N-dimethyl-4,5-epoxymorphin-6-en
ATC code	none
Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class A1 (Narcotic drugs)[1] CA: Schedule I DE: Anlage I (Authorized scientific use only) US: Schedule I
Identifiers
IUPAC name (5α)-6,17-Dimethyl-6,7-didehydro-4,5-epoxymorphinan-3-ol
CAS Number	16008-36-9 Y
PubChem CID	5362518
ChemSpider	4515065 N
UNII	Y460N7W76B
KEGG	D12691 Y
CompTox Dashboard (EPA)	DTXSID60166797
ECHA InfoCard	100.036.474
Chemical and physical data
Formula	C18H21NO2
Molar mass	283.371 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC[C@H]2[C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3C
InChI InChI=1S/C18H21NO2/c1-10-3-5-12-13-9-11-4-6-14(20)16-15(11)18(12,17(10)21-16)7-8-19(13)2/h3-4,6,12-13,17,20H,5,7-9H2,1-2H3/t12-,13+,17-,18-/m0/s1 N Key:CUFWYVOFDYVCPM-GGNLRSJOSA-N N
NY (what is this?)  (verify)

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Methyldesorphine is listed as a Schedule I Narcotic controlled substance under the Controlled Substances Act 1970 in the United States with a DEA ACSCN of 9302 and zero annual aggregate manufacturing quota. The free base conversion ratio of the hydrochloride is 0.89.^[6]