Methylmalonate-semialdehyde dehydrogenase (acylating)
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, methylmalonate-semialdehyde dehydrogenase (acylating) (EC 1.2.1.27) is an enzyme that catalyzes the chemical reaction
| methylmalonate-semialdehyde dehydrogenase (acylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Methylmalonate semialdehyde dehydrogenase tetramer, Bacillus subtilis | |||||||||
| Identifiers | |||||||||
| EC no. | 1.2.1.27 | ||||||||
| CAS no. | 37205-49-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The three substrates of this enzyme are methylmalonic acid semialdehyde, coenzyme A (CoA), and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are propionyl-CoA, carbon dioxide, reduced NADH, and a proton.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating). Other names in common use include MSDH, and MMSA dehydrogenase. This enzyme participates in 3 metabolic pathways: inositol metabolism, valine, leucine and isoleucine degradation, and propanoate metabolism.
