Methylmalonic acid semialdehyde

Methylmalonic acid semialdehyde is an intermediate in the metabolism of thymine and valine.^[1] It is a substrate of the enzyme methylmalonate-semialdehyde dehydrogenase (acylating), which converts it to propionyl-CoA.^[2][3][4]

Methylmalonic acid semialdehyde

+ CoA + NAD⁺

 

 

 

CO₂ + H⁺

 

CO₂ + H⁺

 

Propionyl-CoA

+ NADH

 

Quick facts Names, Identifiers ...

Methylmalonic acid semialdehyde

Names
Preferred IUPAC name 2-Methyl-3-oxopropanoic acid
Other names Methylmalonate semialdehyde
Identifiers
CAS Number	6236-08-4 Y
3D model (JSmol)	Interactive image Interactive image
ChEBI	CHEBI:16256 Y
ChemSpider	290 Y
KEGG	C00349 Y
PubChem CID	296
UNII	036CTC7X1V Y
CompTox Dashboard (EPA)	DTXSID60274265
InChI InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7) Y Key: VOKUMXABRRXHAR-UHFFFAOYSA-N Y InChI=1/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7) Key: VOKUMXABRRXHAR-UHFFFAOYAB
SMILES CC(C=O)C(=O)O O=CC(C(=O)O)C
Properties
Chemical formula	C4H6O3
Molar mass	102.089 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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