Metrenperone

Metrenperone
Clinical data
Other names	R-50970; R50970; R-50,970
Drug class	Serotonin 5-HT2A receptor antagonist
ATC code	None;
Identifiers
	IUPAC name 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2,7-dimethylpyrido[1,2-a]pyrimidin-4-one;
CAS Number	81043-56-3;
PubChem CID	72005;
DrugBank	DB21312;
ChemSpider	65004;
UNII	W1O4FV809G;
KEGG	D05015;
ChEMBL	ChEMBL2104852;
CompTox Dashboard (EPA)	DTXSID20230867 ;
ECHA InfoCard	100.072.413
Chemical and physical data
Formula	C24H26FN3O2
Molar mass	407.489 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CN2C(=NC(=C(C2=O)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F)C)C=C1;
	InChI InChI=1S/C24H26FN3O2/c1-16-3-8-22-26-17(2)21(24(30)28(22)15-16)11-14-27-12-9-19(10-13-27)23(29)18-4-6-20(25)7-5-18/h3-8,15,19H,9-14H2,1-2H3; Key:AXQRPYKSPHUOGZ-UHFFFAOYSA-N;

Metrenperone (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved Name; developmental code name R-50970) is a serotonin 5-HT₂ receptor antagonist which was never marketed.^[1]^[2] The drug also shows lower affinity for the α₁-adrenergic and histamine H₁ receptor and much lower affinity for the dopamine D₂ receptor, but no affinity for the serotonin 5-HT₁ and muscarinic acetylcholine receptors.^[2] It is a weak antagonist of the α₁-adrenergic receptor in addition to its potent serotonin 5-HT_2A receptor antagonism.^[3] Metrenperone has been investigated for use in veterinary medicine to treat acute respiratory distress in cattle and has also been studied for topical treatment of wounds as well as injuries.^[1]^[4]^[5] It was first described in the scientific literature by 1982.^[2]