Mexrenone

Mexrenone
Clinical data
Other names	ZK-32055; SC-25152; 7α-(Methoxycarbonyl)canrenone; 17β-Hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid γ-lactone methyl ester
Identifiers
	IUPAC name methyl (7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-carboxylate;
CAS Number	41020-65-9;
PubChem CID	3082529;
ChemSpider	10257997;
UNII	16FTD41OAV;
CompTox Dashboard (EPA)	DTXSID101045761 ;
Chemical and physical data
Formula	C24H32O5
Molar mass	400.515 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC(=O)[C@@H]4C\C1=C\C(=O)CC[C@]1(C)[C@H]5CC[C@@]3(C)[C@@H](CC[C@]23CCC(=O)O2)[C@H]45;
	InChI InChI=1S/C24H32O5/c1-22-8-4-15(25)12-14(22)13-16(21(27)28-3)20-17(22)5-9-23(2)18(20)6-10-24(23)11-7-19(26)29-24/h12,16-18,20H,4-11,13H2,1-3H3/t16-,17+,18+,20-,22+,23+,24-/m1/s1; Key:ADZYJDJNIBFOQE-RGKMBJPFSA-N;

Mexrenone (code names ZK-32055, SC-25152) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed.^[1]^[2] It is the lactonic form of mexrenoic acid (mexrenoate), and mexrenoate potassium (SC-26714), the potassium salt of mexrenoic acid, also exists.^[3] In addition to the mineralocorticoid receptor, mexrenone also binds to the glucocorticoid, androgen, and progesterone receptors.^[4] Relative to spironolactone, it has markedly reduced antiandrogen activity (approximately one-tenth of the antimineralocorticoid dosage equivalent antiandrogen activity of spironolactone).^[2] Eplerenone is the 9-11α-epoxy analogue of mexrenone.^[5]