Milvexian

Milvexian
Clinical data
Other names	BMS-986177, JNJ-70033093
Routes of; administration	By mouth
ATC code	None;
Legal status
Legal status	Investigational;
Pharmacokinetic data
Elimination half-life	11.4–18.1 h
Identifiers
	IUPAC name (9R,13S)-13-{4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-3-(difluoromethyl)-9-methyl-3,4,7,15-tetraazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),4,14,16-pentaen-8-one;
CAS Number	1802425-99-5;
PubChem CID	118277544;
DrugBank	DB16233;
ChemSpider	76803905;
UNII	0W79NDQ608;
KEGG	D11802;
ChEMBL	ChEMBL4112929;
Chemical and physical data
Formula	C28H23Cl2F2N9O2
Molar mass	626.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1CCC[C@H](n2cnc(-c3cc(Cl)ccc3-n3cc(Cl)nn3)cc2=O)c2cc(ccn2)-c2c(cnn2C(F)F)NC1=O;
	InChI InChI=1S/C28H23Cl2F2N9O2/c1-15-3-2-4-23(20-9-16(7-8-33-20)26-21(36-27(15)43)12-35-41(26)28(31)32)39-14-34-19(11-25(39)42)18-10-17(29)5-6-22(18)40-13-24(30)37-38-40/h5-15,23,28H,2-4H2,1H3,(H,36,43)/t15-,23+/m1/s1; Key:FSWFYCYPTDLKON-CMJOXMDJSA-N;

Milvexian is a factor XIa inhibitor anticoagulant drug. It is taken by mouth. As of late 2021, it was under study for the prevention of blood clots in patients undergoing surgery.^[2] In 2018–2023, Bristol-Myers Squibb studied milvexian for the prevention of stroke.^[3]

Other namesBMS-986177, JNJ-70033093

Routes of
administrationBy mouth

ATC code

None

Legal status

Investigational

Quick facts Clinical data, Other names ...

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Milvexian

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Clinical data

Other names	BMS-986177, JNJ-70033093
Routes of administration	By mouth
ATC code	None
Legal status
Legal status	Investigational
Pharmacokinetic data
Elimination half-life	11.4–18.1 h^[1]
Identifiers
IUPAC name (9R,13S)-13-{4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-3-(difluoromethyl)-9-methyl-3,4,7,15-tetraazatricyclo[12.3.1.0^2,6]octadeca-1(18),2(6),4,14,16-pentaen-8-one
CAS Number	1802425-99-5
PubChem CID	118277544
DrugBank	DB16233
ChemSpider	76803905
UNII	0W79NDQ608
KEGG	D11802
ChEMBL	ChEMBL4112929
Chemical and physical data
Formula	C₂₈H₂₃Cl₂F₂N₉O₂
Molar mass	626.45 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@@H]1CCC[C@H](n2cnc(-c3cc(Cl)ccc3-n3cc(Cl)nn3)cc2=O)c2cc(ccn2)-c2c(cnn2C(F)F)NC1=O
InChI InChI=1S/C28H23Cl2F2N9O2/c1-15-3-2-4-23(20-9-16(7-8-33-20)26-21(36-27(15)43)12-35-41(26)28(31)32)39-14-34-19(11-25(39)42)18-10-17(29)5-6-22(18)40-13-24(30)37-38-40/h5-15,23,28H,2-4H2,1H3,(H,36,43)/t15-,23+/m1/s1 Key:FSWFYCYPTDLKON-CMJOXMDJSA-N