Mir-130 microRNA precursor family
RNA family
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In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156[link removed], MI0000408),[1] and in human (MI0000448[link removed], MI0000748).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034[link removed]). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3] It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.[4]
| mir-130 microRNA precursor family | |
|---|---|
Predicted secondary structure and sequence conservation of mir-130 | |
| Identifiers | |
| Symbol | mir-130 |
| Rfam | RF00258 |
| miRBase | MI0000448 |
| miRBase family | MIPF0000034 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
