Mir-638 microRNA precursor family
From Wikipedia, the free encyclopedia
| mir-638 | |
|---|---|
| Identifiers | |
| Symbol | mir-638 |
| Rfam | RF00978 |
| miRBase family | MIPF0000486 |
| Other data | |
| RNA type | microRNA |
| Domain | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-638 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-638 has been implicated in the pathogenesis of lupus nephritis (LN), with intra-renal expression levels differing between normal and lupus nephritis patients.[1] The degree of difference in expression levels further correlates with the degree of disease severity in each LN patient.
miR-638 and gastric cancer
miR-638 levels are significantly downregulated in gastric cancer cell lines, along with deregulation of 23 other miRNAs.[2] Thus miR-628 is likely to be involved in the development and progression of gastric cancer.
Further applications
miR-638 has additionally been found to be upregulated in the K562 leukaemic cell line.[3]
