Mir-BHRF1-3 microRNA precursor family
RNA family
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The mir-BHRF1-3 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus).[1] In Epstein-Barr virus, mir-BHRF1-3 is found in the 3' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.[2] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-1 and Mir-BHRF1-2.[2]
| mir-BHRF1-3 microRNA precursor family | |
|---|---|
Predicted secondary structure and sequence conservation of mir-BHRF1-3 | |
| Identifiers | |
| Symbol | mir-BHRF1-3 |
| Rfam | RF00367 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain | Viruses |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
BHRF-1-3 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein–Barr virus genome.[3] BHRF-3 has been shown to be expressed in latency-III infected lymphoblasts.[4]
