After graduating from Columbia, Lowe worked at Newsday for 18 years, eventually becoming a news editor. She then became the first woman editor-in-chief of Jet. In 2012, she joined CNN Digital as senior editor for features.
In 2017, she was hired as Director of the Innovation News Center, the multimedia newsroom of the University of Florida. From 2019 through 2021, she also served as president of the Journalism & Women Symposium.
In 2021, she joined Florida A&M University as the dean of the School of Journalism & Graphic Communication. She has been featured by the Nieman Lab's Predictions for Journalism multiple times, an initiative of Harvard University's Neiman Foundation for Journalism.[3]