Khayat's breakthrough came in 2003 when she was chosen to work with Amal Hijazi for Hijazi's music video "Romansyia", which showed Hijazi has a young star who had fallen in love. Mirna went to direct Hijazi's other music videos such as "Bedawwar A Albi" and "Mistanie Eiy" which also gained favourable reviews.[citation needed]
In 2005, Mirna Khayat returned to the music scene with Amal Hijazi's "Baad Sneene"and later "Baheb Noa Kalamak".
In 2007, Khayat directed Nancy Ajram's Gulf song, "Meshtagel Leh". She has also directed some hit music videos such as Melissa's "Leil ya Leil ", "Kam Sana", and "Garahtak".[citation needed]