Mitochondrial ribosomal protein L24

39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene.^[5]

AliasesMRPL24, L24mt, MRP-L18, MRP-L24, mitochondrial ribosomal protein L24

External IDsOMIM: 611836; MGI: 1914957; GeneCards: MRPL24

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 1 (human)^[1]

Quick facts MRPL24, Identifiers ...

MRPL24
Identifiers
Aliases	MRPL24, L24mt, MRP-L18, MRP-L24, mitochondrial ribosomal protein L24
External IDs	OMIM: 611836; MGI: 1914957; GeneCards: MRPL24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 156,737,303 bp[1] End 156,741,590 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 87,826,813 bp[2] End 87,830,979 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas apex of heart muscle of thigh right adrenal gland left adrenal cortex islet of Langerhans right adrenal cortex right lobe of liver gastrocnemius muscle mucosa of transverse colon Top expressed in endocardial cushion seminal vesicula spermatocyte interventricular septum efferent ductule cumulus cell cardiac muscle tissue of left ventricle Gonadal ridge medial ganglionic eminence dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome Cellular component mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 79590 67707 Ensembl ENSG00000143314 ENSMUSG00000019710 UniProt Q96A35 Q9CQ06 RefSeq (mRNA) NM_024540 NM_145729 NM_026591 RefSeq (protein) NP_078816 NP_663781 NP_080867 Location (UCSC) Chr 1: 156.74 – 156.74 Mb Chr 3: 87.83 – 87.83 Mb PubMed search [3] [4]
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its Escherichia coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein.^[5]