Moco RNA motif
RNA family
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The Moco RNA motif is a conserved RNA structure [1] that is presumed to be a riboswitch that binds molybdenum cofactor or the related tungsten cofactor. Genetic experiments support the hypothesis that the Moco RNA motif corresponds to a genetic control element that responds to changing concentrations of molybdenum or tungsten cofactor.[2] As these cofactors are not available in purified form, in vitro binding assays cannot be performed. However, the genetic data, complex structure of the RNA and the failure to detect a protein involved in the regulation suggest that the Moco RNA motif corresponds to a class of riboswitches.
| Moco (molybdenum cofactor) riboswitch | |
|---|---|
 Predicted secondary structure and sequence conservation of MOCO_RNA_motif | |
| Identifiers | |
| Symbol | MOCO_RNA_motif |
| Rfam | RF01055 |
| Other data | |
| RNA type | Cis-reg; riboswitch |
| Domain | Bacteria |
| SO | SO:0005836 |
| PDB structures | PDBe |
