Lowery's first position was as director of the non-profit organisation Ocean Park Community Center in Santa Monica.[1] While there, she founded the Sojourn Shelter for Battered Women and Their Children, which was one of the first such facilities in the state.[2]
In 1984, wanting to help people who had been moved out of California's mental hospitals, she left Ocean Park and started working with philanthropist Frank Rice. Together they founded the Los Angeles Men's Place, based in Skid Row.[3] The facility initially offered night-time support to homeless and mentally ill people. Rice and Lowery later renamed the center LAMP, and expanded it to provide permanent supportive housing and complementary social services, such as counselling and substance abuse treatment.[1][4] The foundation also opened a laundromat on Skid Row, employing homeless people as well as providing a service for them, and later a convenience store and a craft shop.[5]
Lowery's approach was groundbreaking in that her organisation offered help to homeless people without preconditions, and considered housing to be the most crucial service to provide to people in need.[6] Unlike other non-profit foundations or government agencies, no paperwork or identification was required, and clients did not need to overcome drug or alcohol addiction before using the shelters and services.[1] This approach became known as "housing first" and Lowery was considered one of its pioneers.[1][2]
Over the next 20 years Lowery oversaw further development of the center, eventually opening an additional 8 facilities across Los Angeles and employing 80 people. In 2005 she oversaw the construction of a new building, the $1.2 million Frank Rice Safehaven, which houses the organisation's headquarters, a day center and a crisis shelter.[7]
In 2003, Lowery received the Ruth Hollmann Award for Outstanding Contribution to Mental Health from Share! and the Emotional Health Association of California.[8]
In 2016, the California Community Foundation named Lowery one of their 30 Unsung Heroes of Los Angeles County.[4]