Multisynthetase complex auxiliary component p38

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesAIMP2, JTV-1, JTV1, P38, PRO0992, Multisynthetase complex auxiliary component p38, aminoacyl tRNA synthetase complex interacting multifunctional protein 2, HLD17
Quick facts AIMP2, Available structures ...
AIMP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAIMP2, JTV-1, JTV1, P38, PRO0992, Multisynthetase complex auxiliary component p38, aminoacyl tRNA synthetase complex interacting multifunctional protein 2, HLD17
External IDsOMIM: 600859; MGI: 2385237; HomoloGene: 4594; GeneCards: AIMP2; OMA:AIMP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001172146
NM_146165

RefSeq (protein)

NP_001165617
NP_666277

Location (UCSC)Chr 7: 6.01 – 6.02 MbChr 5: 143.84 – 143.85 Mb
PubMed search[3][4]
Wikidata
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Function

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown.[7]

Interactions

Multisynthetase complex auxiliary component p38 has been shown to interact with Parkin (ligase),[8] P53[6] and KARS.[9][10]

References

Further reading

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